2024

Nucleotide excision repair deficiency is a targetable therapeutic vulnerability in clear cell renal cell carcinoma

Aurel Prosz#, Haohui Duan#, Viktoria Tisza#, Pranshu Sahgal, Sabine Topka, Gregory T. Klus, Judit Börcsök, Zsofia Sztupinszki, Timothy Hanlon, Miklos Diossy, Laura Vizkeleti, Dag Rune Stormoen, Istvan Csabai, Helle Pappot, Joseph Vijai, Kenneth Offit, Thomas Ried, Nilay Sethi, Kent W. Mouw, Sandor Spisak*, Shailja Pathania* & Zoltan Szallasi*, Scientific Reports

# These authors contributed equally

* Co-Senior Authors

DOI: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10667362/pdf/41598_2023_Article_47946.pdf

2023

Replication stress and defective checkpoints make fallopian tube epithelial cells putative drivers of highgrade serous ovarian cancer

Pamoda Galhenage, Yunlan Zhou,  Erica Perry, Brenda Loc, Kelly Fietz, Sonia Iyer, Ferenc Reinhardt, Tiego Da Silva, Vladimir Botchkarev, Jie Chen, Christopher P. Crum, Robert A. Weinberg, and Shailja Pathania (2023), Cell Reports 

DOI: https://www.cell.com/cell-reports/pdf/S2211-1247(23)01156-7.pdf

2022

The tumor mutational landscape of BRCA2-deficient primary and metastatic prostate cancer

Kevin H. Kensler, Shakuntala Baichoo, Shailja Pathania, and Timothy R. Rebbeck (2022), NPJ Precision Oncology

DOI: https://doi.org/10.1038/s41698-022-00284-6

2021

BRCA1/Trp53 heterozygosity and replication stress drive esophageal cancer development in a mouse model

Ye He, Joshua Rivera, Miklos Diossy, Haohui Duan, Christian Bowman-Colin, Rachel Reed, Rebecca Jennings, Jesse Novak, Stevenson V. Tran, Elizabeth F. Cohen, View ORCID ProfileDavid Szuts, Anita Giobbie-Hurder, Roderick T. Bronson, Adam J. Bass, Sabina Signoretti, Zoltan Szallasi, David M. Livingston, and Shailja Pathania (2021), PNAS

PNAS October 12, 2021 118 (41) e2108421118; https://doi.org/10.1073/pnas.2108421118

Genetically defined syngeneic mouse models of ovarian cancer as tools for the discovery of combination immunotherapy

RPA, RFWD3, and BRCA2 at stalled forks: a balancing act

Haohui Duan & Shailja Pathania (2020), Molecular & Cellular Oncology

DOI: 10.1080/23723556.2020.1801089

Fibroblast-tumor cell signaling limits HER2 kinase therapy response via activation of MTOR and antiapoptotic pathways.

Zervantonakis IK, Poskus MD, Scott AL, Selfors LM, Lin JR, Dillon DA, Pathania S, Sorger PK, Mills GB, Brugge JS.Proc Natl Acad Sci U S A. 2020 Jul 14;117(28):16500-16508. Epub 2020 Jun 29.PMID: 32601199

DOI: 10.1073/pnas.2000648117

E3 ligase RFWD3 is a novel modulator of stalled fork stability in BRCA2-deficient cells.

Duan H, Mansour S, Reed R, Gillis MK, Parent B, Liu B, Sztupinszki Z, Birkbak N, Szallasi Z, Elia AEH, Garber JE, Pathania S. J Cell Biol. 2020 Jun 1;219(6):e201908192. doi: 10.1083/jcb.201908192.

2019

MAPK Pathway Suppression Unmasks Latent DNA Repair Defects and Confers a Chemical Synthetic Vulnerability in BRAF-, NRAS-, and NF1-Mutant Melanomas.

Maertens O, Kuzmickas R, Manchester HE, Emerson CE, Gavin AG, Guild CJ, Wong TC, De Raedt T, Bowman-Colin C, Hatchi E, Garraway LA, Flaherty KT, Pathania S, Elledge SJ, Cichowski K.Cancer Discov. 2019 Apr;9(4):526-545. doi: 10.1158/2159-8290.CD-18-0879. Epub 2019 Feb 1.

2018

Mixing Mutation Location with Carcinogen Exposure: A Recipe for Tissue Specificity in BRCA2-Associated Cancers?

Pathania S., Garber JE. J Natl Cancer Inst. 2018 Sep 1;110(9):925-926. doi: 10.1093/jnci/djy047.

Overexpression of BLM promotes DNA damage and increased sensitivity to platinum salts in triple negative breast and serous ovarian cancers.

Birkbak NJ*, Li Y*, Pathania S*, Greene-Colozzi A, Dreze M, Bowman-Colin C, Sztupinszki Z, Krzystanek M, Diossy M, Tung N, Ryan PD, Garber JE, Silver DP, Iglehart JD, Wang ZC, Szuts D, Szallasi Z, Richardson AL. *Equal contribution. (2018) Ann Oncol. doi:10.1093/annonc/mdy049.

2016

BRCA1/FANCD2/BRG1-driven DNA Repair Stabilizes the Differentiation State of Human Mammary Epithelial Cells.

Hua Wang, Brian Bierie, Andrew G. Li, Shailja Pathania, Kimberly Toomire, Stoil D Dimitrov, Ben Liu, Rebecca Gelman, Anita Giobbie-Hurder, Jean Feunteun, Kornelia Polyak, and David M. Livingston. Mol Cell. 2016 July 21; 63(2): 277–292.

2015

BRCA1 recruitment to transcriptional pause sites is required for R-loop-driven DNA damage repair. 

Hatchi E, Skourti-Stathaki K, Ventz S, Pinello L, Yen A, Kamieniarz-Gdula K, Dimitrov S, Pathania S, McKinney KM, Eaton ML, Kellis M, Hill SJ, Parmigiani G, Proudfoot NJ, Livingston DM. Mol Cell. 2015 Feb19; 57(4):636-47 . doi: 10.1016/j.mol cel. 2015.01.011.

2014

BRCA1 haploinsufficiency for replication stress suppression in primary cells.

 Pathania S*, Bade S, Le Guillou M, Burke K, Reed R, Bowman-Colin C, Su Y, Ting DT, Polyak K, Richardson AL, Feunteun J, Garber JE, Livingston DM*. Nature Communication. 2014 Nov 17;5:5496. doi: 10.1038/ncomms6496. *co-senior authors.

2013

Physiological modulation of endogenous BRCA1 p220 abundance suppresses DNA damage during the cell cycle.

Dimitrov SD, Lu D, Naetar N, Hu Y, Pathania S, Kanellopoulou C, Livingston DM. . Genes Dev. 2013 Oct 15;27(20):2274-91. doi: 10.1101/gad.225045.113.

2011

BRCA1 is required for postreplication repair after UV-induced DNA damage.

Pathania S, Nguyen J, Hill SJ, Scully R, Adelmant GO, Marto JA, Feunteun J, Livingston DM.  Mol Cell. 2011 Oct 21;44(2):235-51. doi: 10.1016/j.molcel.2011.09.002. Epub 2011 Sep 29.

2009

Cdk1 participates in BRCA1-dependent S phase checkpoint control in response to DNA damage.

Johnson N, Cai D, Kennedy RD, Pathania S, Arora M, Li YC, D’Andrea AD, Parvin JD, Shapiro GI. . Mol Cell. 2009 Aug 14;35(3):327-39. doi: 10.1016/j.molcel.2009.06.036.

2006

Multifactorial contributions to an acute DNA damage response by BRCA1/BARD1-containing complexes.

Greenberg RA, Sobhian B, Pathania S, Cantor SB, Nakatani Y, Livingston DM. Genes Dev. 2006 Jan 1;20(1):34-46