Journal Papers | Review Papers | Books and Book Chapters | Conference Proceedings
Journal Papers
Jump to: 2011-2024 | 2010 and earlier
2011-2024
J. Mata Calidonio, A.I. Maddox, K. Hamad-Schifferli*, “A novel immunoassay technique using principal component analysis for enhanced detection of emerging viral variants,” 2024, Lab on A Chip, 24, 3985-3995.
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J. Mata Calidonio, J. Gomez-Marquez*, K. Hamad-Schifferli*, “Paper Powered Synthesis of Gold Nanoparticles and Metronidazole for Bioassays,” 2024, ACS Applied Nano Materials, 7, 18545-18553.
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J. Mata Calidonio, K. Hamad-Schifferli*, “An approach to use machine learning to optimize paper immunoassays for SARS-CoV-2 IgG and IgM antibodies,” 2024, Sensors and Diagnostics, 3, 677-687.
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C. Rodriguez-Quijada, C. Lyons, M. Sánchez-Purrà, C. Santamaria, B.M. Leonardo, S. Quinn, M. Tlusty*, M. Shiaris*, K. Hamad-Schifferli*, “A gold nanoparticle paper immunoassay for sensing the presence of Vibrio parahaemolyticus in oyster hemolymph,” ACS Omega, 2023, 8, (22) 19494–19502.
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H. Rijal, L. Goggin, R. Muriph, J. Evans*, K. Hamad-Schifferli*, “The influence of preforming protein coronas on the performance of dengue NS1 immunoassays,” Pharmaceutics, 14 2022.
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H. de Puig, I. Bosch, N. Salcedo, C. Clavet, K. Hamad-Schifferli, J. J. Collins, L. Gehrke, “Multiplexed Rapid Antigen Tests Developed using Multicolored Nanoparticles and Cross-Reactive Antibody Pairs: Applications for Pandemic Preparedness,” Nano Today, 2022, 47, 101669.
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D. R. Hristov, H. Rijal, J. Gomez-Marquez, K. Hamad-Schifferli, “Developing a paper-based antigen assay to differentiate between coronaviruses and SARS-CoV-2 Spike variants,” Analytical Chemistry, 2021, 93 (22), 7825-7832.
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D. R. Hristov, A. J. Pimentel, G. Ujialele, K. Hamad-Schifferli, “The immunoprobe aggregation state is central to dipstick immunoassay performance,” ACS Applied Materials and Interfaces, 2020, 12 (31), 34620-34629.
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C. Rodriguez-Quijada, J. Gomez-Marquez, K. Hamad-Schifferli, “Repurposing Old Antibodies for New Diseases by Exploiting Cross-Reactivity and Multicolored Nanoparticles,” ACS Nano, 2020, 14 (6), 6626–6635.
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C. Rodriguez-Quijada, C. Lyons, C. Santamaria, S. Quinn, M. Tlusty, M. Shiaris, K. Hamad-Schifferli, “Optimization of paper-based nanoparticle immunoassays for direct detection of the bacterial pathogen V. parahaemolyticus in oyster hemolymph.” Analytical Methods, 2020, in themed collection Bioanalytical sensors for real world applications, 12, 3056-3063.
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L. Russo, M. Sánchez-Purrà, C. Rodriguez-Quijada, B. M. Leonardo, V. Puntes*, and K. Hamad-Schifferli*, “Detection of resistance protein A (MxA) in paper-based immunoassays with surface enhanced Raman spectroscopy with AuAg nanoshells,” Nanoscale, 2019, 11 10819-10827.
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S. Wick, D. I Walsh III, J. Bobrow, K. Hamad-Schifferli, D. S. Kong, T. Thorsen, K. Mroszczyk, P.A. Carr, “PERSIA for Direct Measurement of Transcription, Translation, and Enzyme Activity in Cell-Free Systems,” 2019, ACS Synthetic Biology, 8 (5) 1010-1025.
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C. Rodriguez-Quijada, H. de Puig, M Sánchez-Purrà, C. Yelleswarapu, J. J. Evans, J. P. Celli, K. Hamad-Schifferli, “Protease degradation of protein coronas and its impact on cancer cells and drug payload release,” ACS Applied Materials and Interfaces, 2019, 11 (16), 14588–14596.
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M. Sánchez-Purrà, B. Roig-Solvas, C. Rodriguez-Quijada, B.M. Leonardo, and K. Hamad-Schifferli, “Reporter selection for Nanotags in Multiplexed Surface Enhanced Raman Spectroscopy Assays,” 2018, ACS Omega, 3 (9) 10733–10742.
Link (Open Access)
E. Phillips, A. K. Young, N. Albarran, J. Butler, K. Lujan, K. Hamad-Schifferli, J. Gomez-Marquez, “Ampli: A Construction Set for Paperfluidic Systems,” Advanced Healthcare Materials, 2018,1800104.
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I. Bosch,* H. de Puig,* M. Hiley, M. Carré-Camps, F. Perdomo-Celis, C. F. Narváez, D. M. Salgado, D. Senthoor, M. O’Grady, E. Phillips, A. Durbin, D. Fandos, H. Miyazaki, C.-W. Yen, M. Gélvez-Ramírez, R. V. Warke, L. S. Ribeiro, M. M. Teixeira, R. P. Almeida, J. E. Muñóz-Medina, J. Ludert, M. L. Nogueira, T. E. Colombo, A. C. B. Terzian, P. T. Bozza, A. S. Calheiros, Y. R. Vieira, G. Barbosa-Lima, A. Vizzoni, J. Cerbino-Neto, F. A. Bozza, T. M. L. Souza, M. R. O. Trugilho, A. M. B. de Filippis, P. C. de Sequeira, E. T. A. Marques, T. Magalhaes, F. J. Díaz, B. N. Restrepo, K. Marín, S. Mattar, D. Olson, E. J. Asturias, M. Lucera, M. Singla, G. R. Medigeshi, N. de Bosch, J. Tam, J. Gómez-Márquez, C. Clavet, L. Villar, K. Hamad-Schifferli,† L. Gehrke† “Rapid antigen tests for dengue virus serotypes and Zika virus in patient serum,” 2017, Science Translational Medicine, 9, eaan1589.
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M. Sánchez-Purrà, B. Roig-Solvas, A.Versiani, C. Rodriguez-Quijada, H. de Puig, I. Bosch, L. Gehrke, K. Hamad-Schifferli, “Design of SERS nanotags for multiplexed lateral flow immunoassays,” 2017, Molecular Systems Design & Engineering, 2, 401-409.
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M. Sánchez-Purrà, M. Carré-Camps, H. de Puig, I. Bosch, L. Gehrke, K. Hamad-Schifferli, “SERS-based sandwich immunoassays for multiplexed detection of Zika and dengue viral biomarkers,” 2017, ACS Infectious Diseases, 3 (10), 767-776.
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J. Gao, M. Sánchez-Purrà, H. Huang, S. Wang, Y. Chen, X. Yu, Q. Luo, K. Hamad-Schifferli*, S. Liu*, “Synthesis of different-sized gold nanostars for Raman bioimaging and photothermal therapy in cancer nanotheranostics,” 2017, Science China Chemistry, 60, 1219–1229.
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H. de Puig, I. Bosch, M. Carre-Camps, K. Hamad-Schifferli, “Effect of the protein corona on antibody-antigen binding in nanoparticle sandwich immunoassays,” 2017, Bioconjugate Chemistry, 28 (1), 230-238.
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J. O. Tam, H. de Puig, C. Yen, I. Bosch, J. Gomez-Marquez, C. Clavet, K. Hamad-Schifferli,* L. Gehrke,* “A Comparison of Nanoparticle-Antibody Conjugation Strategies in Sandwich Immunoassays,” 2017, Journal of Immunoassay and Immunochemistry, 38, 355-377.
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H. de Puig, J. O. Tam, C. Yen, L. Gehrke,* K. Hamad-Schifferli,* “The Extinction Coefficient of Gold Nanostars,” 2015, Journal of Physical Chemistry C, 119, 17408-17415.
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V. Liberman,* K. Hamad-Schifferli, T. A. Thorsen, S. T. Wick, P. A. Carr, “In-situ microfluidic SERS assay for monitoring enzymatic breakdown of organophosphates,” 2015, Nanoscale, 7, 11013-11023.
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C. Yen, H. de Puig, J. O. Tam, J. Gomez-Marquez, I. Bosch, K. Hamad-Schifferli,* and L. Gehrke*, “Multicolored Silver Nanoparticles for Multiplexed Disease Diagnostics: Distinguishing Dengue, Yellow Fever, and Ebola Viruses,” 2015, Lab on a Chip, 15, 1638-1641.
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The top-scoring Altmetrics article (#1 of of 1410 articles) published in Lab on a Chip January-March 2015.
J. C. Y. Kah, C. Grabinski, E. Untener, C. Garrett, J. Chen, D. Zhu, S. M. Hussain+, and K. Hamad-Schifferli+, “Protein Coronas on Gold Nanorods Passivated with Amphiphilic Ligands Affect Cytotoxicity and Cellular Response to Penicillin/Streptomycin,” 2014, ACS Nano, 8, 4608-4620.
+corresponding authors
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A. Cifuentes Rius*, H. de Puig*, J. C. Y. Kah, S. Borros, and K. Hamad-Schifferli, “Optimizing the Properties of the Protein Corona Surrounding Nanoparticles for Tuning Payload Release,” 2013, ACS Nano, 7, 10066-10074.
* equally contributing authors
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P. Ciaurriz Gortari, E. Bravo, and K. Hamad-Schifferli, “Effect of architecture on the activity of glucose oxidase/horseradish peroxidase/carbon nanoparticle conjugates,” 2013, Journal of Colloid and Interface Science, 414, 73-81.
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H. de Puig, A. Cifuentes Rius, D. C. Flemister, S. H. Baxamusa, and K. Hamad-Schifferli, “Selective Light-Triggered Release of DNA from Gold Nanorods Switches Blood Clotting On and Off,” 2013, PLOS ONE, 8, e68511.
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J. Suntivich, Z. Xu, C. Carlton, J. Kim, B. Han, S. W. Lee, N. Bonnet, N. Marzari, L. Allard, H. A. Gasteiger, K. Hamad-Schifferli, and Y. Shao-Horn, “Surface Composition Tuning of Au-Pt Bimetallic Nanoparticles for Enhanced Carbon Monoxide and Methanol Electro-oxidation,” 2013, Journal of the American Chemical Society, 135 (21) 7985-7991.
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D. Maiolo, S. Federici, L. Ravelli, L. Depero, K. Hamad-Schifferli, and P. Bergese, “Nanomechanics of surface DNA switches probed by captive contact angle,” 2013, Journal of Colloid and Interface Science, 402, 334-339.
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K. Hamad-Schifferli, “How Can We Exploit the Protein Corona?” 2013, Nanomedicine, 8 (1) 1-3, invited Editorial.
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J. C. Y. Kah, J. Chen, A. Zubieta, and K. Hamad-Schifferli, “Exploiting the Protein Corona Around Gold Nanorods for Loading and Triggered Release,” 2012, ACS Nano, 6 (8), 6730-6740.
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Z. Xu, E. Lai, Y. Shao-Horn*, and K. Hamad-Schifferli*, “Compositional dependence of the stability of AuCu alloy nanoparticles,” ChemComm, 2012, 48, 5626-5628.
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J. C. Y. Kah, A. Zubieta, R. Saavedra, and K. Hamad-Schifferli, “Stability of gold nanorods passivated with amphiphilic ligands,” Langmuir, Special Issue on Colloidal Nanoplasmonics, invited submission, 2012, 28 (24), 8834-8844, invited submission.
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E. Tellechea, K. J. Wilson, E. Bravo, and K. Hamad-Schifferli, “Engineering the Interface between Glucose Oxidase and Nanoparticles” Langmuir, 2012, 28 (11), 5190-5200.
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H. de Puig*, S. Federici*, S. H. Baxamusa, P. Bergese+, and K. Hamad-Schifferli+, “Quantifying the nanomachinery of the nanoparticle-biomolecule interface,” Small, 2011, 7 (17), 2477-2484.
* equally contributing authors
+ corresponding authors
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C. Grabinski, N. Schaeublin, A. Wijaya, H. D’Couto, S. H. Baxamusa, K. Hamad-Schifferli, and S. M. Hussain, “Effect of Gold Nanorod Surface Chemistry on Cellular Response,” ACS Nano, 2011, 5 (4), 2870-2879.
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2010 and earlier
S. Federici, G. Oliviero, K. Hamad-Schifferli, and P. Bergese, “Protein Thin Film Machines,” Nanoscale, 2010, 2, 2570-2574.
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Z. Xu, C. Carlton, L. F. Allard, Y. Shao-Horn, and K. Hamad-Schifferli, “Direct Colloidal Route for Pt-Covered AuPt Bimetallic Nanoparticles,” Journal of Physical Chemistry Letters, 2010, 1 (17), 2514-2518.
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S. Park, N. Sinha, K. Hamad-Schifferli, “Effective Size and Zeta Potential of Nanorods by Ferguson Analysis,” Langmuir, 2010, 26 (16), 13071-13075.
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Y.-C. Lu, Z. Xu, H. A. Gasteiger, S. Chen, K. Hamad-Schifferli, and Y. Shao-Horn, “Platinum-Gold Nanoparticles: A Highly Active Bifunctional Electrocatalyst for Rechargeable Lithium-Air Batteries,” JACS, 2010, 32 (135), 12170-12171.
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S. Park and K. Hamad-Schifferli, “Enhancement of in vitro translation by gold nanoparticle-DNA conjugates,”ACS Nano, 2010, 4 (5), 2555-2560.
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J. D. Alper and K. Hamad-Schifferli, “Effect of ligand on thermal dissipation from gold nanorods,” Langmuir, 2010, 26 (6), 3786-3789.
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J. D. Alper, M. Crespo, K. Hamad-Schifferli, “Release mechanism of octadecyl rhodamine B chloride from Au nanorods by ultrafast laser pulses,” Journal of Physical Chemistry C, 2009, 113 (15), 5967-5973.
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M.-E. Aubin-Tam, W. Hwang, K. Hamad-Schifferli, “Site-directed nanoparticle labeling of cytochrome c,” PNAS, 2009, 106 (11), 4095-4100.
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Featured in the Virtual Journal of Biological Physics Research, April 1, 2009, 17 (7).
A. Wijaya, S. B. Schaffer, I. G. Pallares, K. Hamad-Schifferli, “Selective release of multiple DNA oligonucleotides from gold nanorods,” ACS Nano, 2009, 3(1), 80-86.
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Featured in the Virtual Journal of Drug Delivery, ACS Nano, February 22, 2011, 1 (2).
A. Wijaya and K. Hamad-Schifferli, “Ligand customization and DNA functionalization of gold nanorods via roundtrip phase transfer ligand exchange,” Langmuir, 2008, 24, 9966-9969.
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A. J. Schmidt,* J. D. Alper,* M. Chiesa, G. Chen, S. K. Das, K. Hamad-Schifferli, “Probing the gold nanorod-ligand-solvent interface by plasmonic absorption and thermal decay,” Journal of Physical Chemistry C, 2008, 112, 13320-13323.
*These authors contributed equally to the work.
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S. Park and K. Hamad-Schifferli, “Evaluation of hydrodynamic size and zeta-potential of surface-modified Au nanoparticle-DNA conjugates via Ferguson analysis,” Journal of Physical Chemistry C, 2008, 112, 7611-7616.
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K. A. Brown, S. Park, K. Hamad-Schifferli, “Nucleotide-Surface interactions in DNA modified Au-Nanoparticle Conjugates: Sequence Effects on Reactivity and Hybridization,” Journal of Physical Chemistry C, 2008, 112, 7517-7521.
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M.-E. Aubin-Tam, H. Zhou, and K. Hamad-Schifferli, “Structure of cytochrome c at the interface with magnetic CoFe2O4 nanoparticles,” Soft Matter, 2008, 4, 554-559.
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A. Wijaya and K. Hamad-Schifferli, “High density encapsulation of Fe3O4 nanoparticles in lipid vesicles,” Langmuir, 2007, 23 (19) 9546-9550.
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Langmuir’s Most-Accessed Articles: July-September, 2007
A. Wijaya, K. A. Brown, J.D. Alper, and K. Hamad-Schifferli, “Magnetic field heating study of Fe doped Au nanoparticles,” Journal of Magnetism and Magnetic Materials, 2007, 309 (1) 15-19.
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M.-E. Aubin-Tam and K. Hamad-Schifferli, “Gold nanoparticle-cytochrome c complexes: the effect of nanoparticle ligand charge on protein structure,” Langmuir, 2005, 21 (26) 12080 – 12084.
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Langmuir’s Most-Accessed Articles: October-December, 2005
M.-E. Aubin, D.G. Morales, K. Hamad-Schifferli, “Labeling Ribonuclease S with a 3nm Au nanoparticle by two-step assembly,” Nano Letters, 2005, 5, 519-522.
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S. Park, K. A. Brown, K. Hamad-Schifferli, “Changes in oligonucleotide conformation on nanoparticle surfaces by modification with mercaptohexanol,” Nano Letters, 2004, 4, 1925-1929.
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K. Hamad-Schifferli, J.J. Schwartz, A.T. Santos, S. Zhang, J.M. Jacobson, “Remote electronic control of DNA hybridization through inductive coupling to an attached metal nanocrystal antenna,” Nature, 2002, 415, 152-155.
K. S. Hamad, R. Roth, J. Rockenberger, T. van Buuren, and A. P. Alivisatos, “Structural disorder in colloidal InAs and CdSe nanocrystals observed by XANES,” Physical Review Letters, 1999, 83(17), 3474-77.
A. A. Guzelian, J. E. B. Katari, A.V. Kadavanich, U. Banin, K. Hamad, E. Juban, A. P. Alivisatos, R. H. Wolters, C. C. Arnold, J.R. Heath, “Synthesis of Size-Selected, Surface Passivated InP Nanocrystals,” Journal of Physical Chemistry, 1996, 100, 7212-7219.
Editorials
K. Hamad-Schifferli, “How can we exploit the protein corona?” Nanomedicine, 2013, 8 (1), 1-3, invited editorial.
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Review Papers
J. Mata Calidonio, K. Hamad-Schifferli, “Biophysical and biochemical insights in the design of immunoassays,” Biochimica et Biophysica Acta–General Subjects, 2023, 1867 (1), 130266.
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J. Mata Calidonio, J. Gomez-Marquez, K. Hamad-Schifferli, “Nanomaterial and interface advances in immunoassay biosensors,” Journal of Physical Chemistry C, 2022, 126 (42) 17804–17815.
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D. R. Hristov, J. Gomez-Marquez, D. Wade, and K. Hamad-Schifferli*, “SARS-CoV-2 and approaches for testing and diagnostic strategy,” Journal of Materials Chemistry B, 2021, 9, 8157-8173.
Link.
J. Gomez-Marquez* and K. Hamad-Schifferli*, “Local development of nanotechnology-based diagnostics,” Nature Nanotechnology, 2021.
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J. Gomez-Marquez and K. Hamad-Schifferli, “Distributed Biological Foundries for Global Health,” Advanced Healthcare Materials, 2019, 1900184.
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D. R. Hristov, C. Rodriguez-Quijada, J. Gomez-Marquez, K. Hamad-Schifferli, “Designing Paper-Based Immunoassays for Biomedical Applications,” 2019, Sensors, Review Article for special issue on “Biosensors,” 2019, 19 (3), 554, invited submission.
Link (Open Access)
C. Rodriguez-Quijada,† M. Sánchez-Purrà,† H. de Puig, and K. Hamad-Schifferli, “Physical Properties of Biomolecules at the Nanomaterial Interface,” 2018, Journal of Physical Chemistry B, Feature Article, 2018, 122 (11), 2827-2840.
†Equally contributing authors.
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H. de Puig, I. Bosch, L Gehrke, K. Hamad-Schifferli, “Challenges of the nano-bio interface in lateral flow and dipstick immunoassays,” 2017, Trends in Biotechnology, 35 (12), 1169-1180
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K. Hamad-Schifferli, “Exploiting the novel properties of protein coronas: Emerging applications in nanomedicine,” 2015, Nanomedicine, 10, 1663-1674, invited contribution.
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S. Park and K. Hamad-Schifferli, “Nanoscale Interfaces to Biology,” Current Opinion in Chemical Biology, Special issue on Nanotechnology and Miniaturization, 2010, 14 (5), 616-622.
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M.-E. Aubin-Tam, K. Hamad-Schifferli, “Structure and Function of Nanoparticle-Protein Conjugates,” Biomedical Materials, special issue: Advanced methods and protocols for the biomedical sciences, 2008, 3, 034001 , invited contribution.
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Featured in “Highlights of 2008” for Biomedical Materials
K. Hamad-Schifferli, “Control of biomolecular activity by nanoparticle antennas,” in BioMEMS and Biomedical Nanotechnology, vol II:Micro/Nano Technologies for Genomics and Proteomics, edited by Mihri Ozkan and Michael Heller (Kluwer, New York, 2006), invited contribution.
K. Hamad-Schifferli, in Encyclopedia of Nanoscience and Nanotechnology, edited by J. A. Schwarz, C. Contescu and K. Putyera (Marcel Dekker, New York, 2004), invited contribution.
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Books and Book Chapters and Editing
S. Quinn, J. Mata Calidonio, K. Hamad-Schifferli, “Green and sustainable paper-based sensing systems using nanoparticles,” 2024, Encyclopedia of Green Chemistry, edited by B. Torok, in press.
K. Hamad-Schifferli, “Applications of Gold Nanoparticles in Plasmonic and Nanophotonic Biosensing,” in Trends in Biosensing Research: Advances, Challenges and Applications, Eds. Fred Lisdat and Nicolas Plumeré, 2024.
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K. Hamad-Schifferli, “Nano-Bio Interfaces in Colloids and Nanoparticles,” in One Hundred Years of Colloid Symposia: Looking Back and Looking Forward, Ed. Ramanathan Nagarajan, 2023.
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K. Hamad-Schifferli, Nanoparticle-Cell Interactions, in: L. Liz-Marzán (Ed.) WSPC Reference on Plasmonic Nanomaterials: Principles, Design and Bio-applications, World Scientific Publishing Company, 2022.
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A. Boccaccini, K. Hamad-Schifferli, M. McAlpine, J. Song, Guest eds., Collection on Opens Biomaterials Research, PLoS ONE, 2019.
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C. Rodriguez-Quijada and K. Hamad-Schifferli, “Applications of Plasmonic Nanomaterials for Phototriggered Theranostics,” in the Handbook of Nanomaterials for Cancer Theranostics: from the Chemical to the Biological Realm. Elsevier, Advanced Nanomaterials book series, edited Ashutosh Tiwari, 2018, invited contribution.
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K. Hamad-Schifferli, “Stability of Dispersions and interactions in nanostructured Fluids,” in “Colloidal Foundations of Nanoscience: the legacy of the world of neglected dimensions for nanotechnology,” Debora Berti & Gerardo Palazzo, eds., (Elsevier, 2014), invited contribution.
P. Bergese and K. Hamad-Schifferli, eds., “Nanomaterial Interfaces to Biology,” Methods in Molecular Biology, XIV, vol. 1025, Series Editor John Walker, (Humana, Totowa, NJ, 2013).
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Conference Proceedings
K. Hamad-Schifferli, “Controlling Blood Clotting by Laser Triggered Release From Gold Nanorods,” in Advanced Photonics 2016 (IPR, NOMA, Sensors, Networks, SPPCom, SOF), OSA Technical Digest (online) (Optical Society of America, 2016), paper SeW3E.2.
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L. G. Griffith and K. Hamad-Schifferli, “Teaching the Second Law: Statistical Mechanics of Biomolecular Systems,” Proceedings from the Keenan Symposium: Meeting the Entropy Challenge, Cambridge MA, 2007.
H. Zhou and K. Hamad-Schifferli, “Control of Enzymatic Activities by Magnetite Nanoparticles,” Proceedings from the Materials Research Society Symposium, Boston, MA, 2006, 950E.
A. Wijaya, K. A. Brown, J.D. Alper, and K. Hamad-Schifferli, “Selective Heating of Multiple Nanoparticles,” Proceedings from the Materials Research Society Symposium, Boston, MA, 2005, 900E, 0900-O09-40.1-6
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K. A. Brown, A. Wijaya, J.D. Alper, and K. Hamad-Schifferli, “Synthesis of water-soluble, magnetic Fe/Au nanoparticles,” Proceedings from the Materials Research Society Symposium, Boston, MA, 2005, 900E, 0900-O07-01.1-6
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M.-E. Aubin-Tam and K. Hamad-Schifferli, “Site-Specific Labeling of Active Proteins with Gold Nanoparticles,” Proceedings from the Materials Research Society Symposium, Boston, MA, 2005, 900E, 0900-OO02-03.1-6.
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K. Hamad-Schifferli, J.J. Schwartz, A.T. Santos, S. Zhang, J.M. Jacobson, “Direct Electronic Control of Biomolecular Systems: Using Nanocrystals as Antennas for Regulation of Biological Activity,” Proceedings from the Materials Research Society Symposium, San Francisco, CA, 2001, Y8.43.1-6